Cancer Cachexia

Table of Contents

Cancer Cachexia

Mechanism of Cachexia

Cancer Cachexia

Proposed Protocol

SEAP values in pigs injected with 500 mcg SP-SEAP construct into different skeletal muscles

Evidence for Benefit from GHRH/GH/IGF1 pathway

Evidence for Role of GHRH/GH/IGF1 pathway (2)

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Evidence for Role of GHRH/GH/IGF1 pathway (2)

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Evidence for Role of GHRH/GH/IGF1 pathway (2)

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Evidence for Role of GHRH/GH/IGF1 pathway (2)

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Evidence for Role of GHRH/GH/IGF1 pathway (2)

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Evidence for Role of GHRH/GH/IGF1 pathway (3)

Companion Dog Cancer Model – Pros and Cons

Advantages of GHRH over GH 

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Advantages of GHRH over synthetic Peptide

Cancer Risks

“Cancer should no longer be a contraindication for the administration of Growth Hormone”

Minimizing Cancer Risks

Companion Dog Cancer Model – Pros and Cons

Function of Gene Switch in Large Animals (Pigs)

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Function of Gene Switch in Large Animals

Increase in IGF-I in Plasmid treated Pigs before and after MFP

Function of Gene Switch in Large Animals

Increase in IGF-I in Plasmid treated Pigs before and after MFP

Why MFP-Inducible System?

Minimizing Cancer Risks

Capacity to Perform the Study

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Gene Transfer Clinical Protocols

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Relative Risks of Gene Transfer versus Risks of Hormone/Peptide

Risks of Adding Inducible System should be Low

Summary

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IGF-I levels in Pigs treated with GHRH-IS and MFP

Evidence for Role of GHRH/GH/IGF1 pathway (2)

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