Cancer Cachexia

Mechanism of Cachexia

Cancer Cachexia

Proposed Protocol

SEAP values in pigs injected with 500 mcg SP-SEAP construct into different skeletal muscles

Evidence for Benefit from GHRH/GH/IGF1 pathway

Evidence for Role of GHRH/GH/IGF1 pathway (2)

PPT Slide

Evidence for Role of GHRH/GH/IGF1 pathway (2)

PPT Slide

Evidence for Role of GHRH/GH/IGF1 pathway (2)

PPT Slide

Evidence for Role of GHRH/GH/IGF1 pathway (2)

PPT Slide

Evidence for Role of GHRH/GH/IGF1 pathway (2)

PPT Slide

Evidence for Role of GHRH/GH/IGF1 pathway (3)

Companion Dog Cancer Model – Pros and Cons

Advantages of GHRH over GH 

PPT Slide

Advantages of GHRH over synthetic Peptide

Cancer Risks

“Cancer should no longer be a contraindication for the administration of Growth Hormone”

Minimizing Cancer Risks

Companion Dog Cancer Model – Pros and Cons

Function of Gene Switch in Large Animals (Pigs)

PPT Slide

Function of Gene Switch in Large Animals

Increase in IGF-I in Plasmid treated Pigs before and after MFP

Function of Gene Switch in Large Animals

Increase in IGF-I in Plasmid treated Pigs before and after MFP

Why MFP-Inducible System?

Minimizing Cancer Risks

Capacity to Perform the Study

PPT Slide

PPT Slide

Gene Transfer Clinical Protocols

PPT Slide

PPT Slide

Relative Risks of Gene Transfer versus Risks of Hormone/Peptide

Risks of Adding Inducible System should be Low

Summary