National Institutes of Health - WEBCAST - March 15 2005




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	National Institutes of Health Recombinant DNA Advisory Committee (RAC) Gene Transfer Safety Symposium: Current Perspectives on Gene Transfer for X-SCID Bethesda Marriott Hotel Bethesda , Maryland Tuesday, March 15, 2005 Morning Session before break (Real Video) Morning Session after break (Real Video) Afternoon Session after lunch (Real Video) Afternoon Session after break (Real Video) CAPTION TEXT (HTML) NOTE: The caption text is a record of the close captioning offered to support the video. It is not a totally accurate, verbatim transcript of the meeting. It is offered here for interest and support of the video. A correct transcript will be available on the NIH web site in due course. Symposium Agenda 8:00 AM Welcome (Real Video) Amy P. Patterson, M.D., Office of Biotechnology Activities, NIH Diane W. Wara, M.D., University of California, San Francisco Presentation (PDF 3MB) 8:10 AM Keynote Speaker Theodore Friedmann, M.D., University of California, San Diego Presentation (PDF 439k) (Real Video) 8:25 AM Current SCID Gene Transfer Experience Moderators: Diane W. Wara, M.D., University of California, San Francisco Bernard Lo, M.D., University of California, San Francisco (Real Video) Approaches to the Patient with X-Linked SCID Who Has Failed Standard BMT Treatment Jennifer M. Puck, M.D., National Human Genome Research Institute, NIH (Real Video) Preliminary Results of an NIH Trial of Retroviral IL2RG Gene Transfer as Salvage Treatment for Older Post-BMT SCID Patients Harry L. Malech, M.D., National Institute of Allergy and Infectious Diseases, NIH Presentation (PDF 1.6MB) (Real Video) Retroviral Gene Transfer for Treatment of X-SCID and ADA-SCID Fabio Candotti, M.D., National Human Genome Research Institute, NIH Presentation (PDF 692k) (Real Video) Summary of Recent Safety Data Emerging from French X-SCID Trial Theodore Friedmann, M.D., University of California, San Diego (Real Video) U.S. Food and Drug Administration Perspectives Carolyn A. Wilson, Ph.D., U.S. Food and Drug Administration Presentation (PDF 53k) (Real Video) 10:15 AM Discussion (Real Video) 10:30 AM - BREAK 10:45 AM Cont Discussion (Real Video) 11:30 AM Retrovirus Integration and Insertional Mutagenesis (Real Video) Moderators: Naomi Rosenberg, Ph.D., Tufts University Marina O’Reilly, Ph.D., Office of Biotechnology Activities, NIH Gene Transfer and Insertional Mutagenesis Christof von Kalle, M.D., Cincinnati Children’s Hospital Medical Center Presentation (PDF 2.2MB) Gene Transfer Insertional Mutagenesis Insights Neal G. Copeland, Ph.D., National Cancer Institute, NIH Presentation (PDF 1.6MB) Retroviral Integration Target Site Preferences Frederic D. Bushman, Ph.D., University of Pennsylvania Presentation (PDF 1MB) 12:45 PM Discussion Disscusion Questions Presentation (PDF 1.3MB) 1:30 PM Lunch 2:30 PM Bone Marrow Transplantation for SCID (Real Video) Moderators: Bernard Lo, M.D., University of California, San Francisco Theodore Friedmann, M.D., University of California, San Diego Thomas Holohan, M.D., Office of Biotechnology Activities, NIH Overview of HLA Identical and Haploidentical BMT: Duke Experience Rebecca H. Buckley, M.D., Duke University Medical Center Presentation (PDF 675k) Overview of HLAIdentical and Haploidentical BMT: Memorial Sloan-Kettering Experience Richard J. O’Reilly, M.D., Memorial Sloan-Kettering Cancer Center Presentation (PDF 868k) Overview of Cord Blood Transplantation John E. Wagner, M.D., University of Minnesota Presentation (PDF 921k) 4:00 PM - BREAK 4:15 PM - Discussion / Wrap-Up and Next Steps (Real Video) Moderators: Theodore Friedmann, M.D., University of California, San Diego Diane W. Wara, M.D., University of California, San Francisco Amy P. Patterson, M.D., Office of Biotechnology Activities, NIH 6:00 PM Adjournment This webcast produced by